Spinal neural cyclooxygenase-2 mediates pain caused in a rat model of lumbar disk herniation.
نویسندگان
چکیده
UNLABELLED Application of nucleus pulposus to nerve root generates radicular pain. We demonstrated that these animals showed allodynia for 2 weeks, and cyclooxygenase-2 (COX-2) immunoreactivities were up-regulated in the spinal dorsal horn. COX-2 immunoreactivities were shown in neurons; however, they were not in astrocytes. Intrathecal administration of an antibody to COX-2 decreased allodynia. Our results suggest that COX-2 in spinal cord might be a target for treatment of patients with nerve root pain caused by lumbar disk herniation. PERSPECTIVE Neural COX-2 might mediate nerve root pain in the spinal cord caused by lumbar disk herniation in rats.
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عنوان ژورنال:
- The journal of pain : official journal of the American Pain Society
دوره 5 7 شماره
صفحات -
تاریخ انتشار 2004